Newly isolated marine Bacillus pumilus (SP21): A source of novel lipoamides and other antimicrobial agents*
نویسندگان
چکیده
A screening of marine bacteria for antimicrobial activity resulted in the isolation of Bacillus pumilus (SP21) from a sediment sample collected in the Bahamas. A bioassayguided fractionation led to the isolation of five surfactin analogs, glycocholic acid, amicoumacins A and B in addition to three new compounds named lipoamides A–C. The chemical structure of all the bioactive compounds was elucidated using spectroscopic methods including 2D NMR and MS. The antimicrobial activity of each compound was evaluated against a panel of pathogens and is reported herein.
منابع مشابه
بررسی فعالیت ضد میکروبی فرآوردههای طبیعی گونههای باسیلوس جدا شده از رسوبات بستر دریای مازندران
Background and purpose: Research for discovery and development of new and effective antimicrobial agents has been raised due to increasing rate of numerous multi-drug resistant pathogens. Marine bacteria especially Bacillus species are a rich source of potentially versatile secondary metabolites with antimicrobial activities. In this study, sediments of the Caspian Sea were screened for natural...
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